By Joel Kaye, DVM
Angell General Medicine Service
Canine Cognitive Dysfunction is an age-related onset of impaired cognitive behaviors that cannot be wholly attributed to sensory or motor impairment or other medical conditions.
Canine Cognitive Dysfunction shares some similarities with human Alzheimer’s disease. Both experience amyloid plaques, impaired glucose metabolism, and free oxygen radical damage. People also undergo a change called neurofibrillary tangles that dogs do not. This is likely due to the fact that pets do not live as long as humans.
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Many of these symptoms overlap with many of the metabolic and neurologic diseases that can be seen in older pets. It is imperative the pet have a full exam, general lab tests and possibly a neurologic exam to rule out other causes. Medical problems must be eliminated before senile symptoms can be attributed to cognitive dysfunction. There is no one specific test for cognitive dysfunction. The chart below summarizes some of the changes to look for in your pet. Up to 50% of pets over the age of 10 will demonstrate one or more of these behaviors indicating some degree of cognitive decline.
There is only one FDA-recognized treatment for Canine Cognitive Dysfunction; a drug called Anipryl-Selegiline Hydrochloride which does the following:
Other treatment options include Nicergoline and Propentofylline which have neuroprotective properties based on their ability to promote blood flow to the brain.
Additional treatment options that have focused on nutritional supplements include:
Keeping your pet physically and mentally active and at a good weight can possibly help prevent Cognitive Dysfunction and promote overall health. Toys that make your pet think to get food or rewards are a good way to keep them mentally sharp. Also practicing preventative health by visiting your veterinarian at the first signs of behavioral and or medical changes is imperative.
For more information, call Angell's General Medicine Service at 617-524-5653.