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Acute Vestibular Disease in Old Dogs

Jennifer Michaels, DVM, DACVIM (Neurology)
www.angell.org/neurology
neurology@angell.org
617-541-5140

Vestibular disease is a common clinical presentation in dogs with neurologic dysfunction. The vestibular system is the system of balance and equilibrium and is comprised of the inner ear (saccule and utricle), vestibular portion of the vestibulocochlear nerve (cranial nerve VIII), the brainstem, and the vestibulocerebellum (flocculonodular lobe, fastigial nucleus, and caudal cerebellar peduncle). Dysfunction in any of these regions will result in similar vestibular symptoms including a head tilt, leaning or falling to one side, tight circling, pathologic nystagmus, and/or positional ventrolateral strabismus (see Figure 1). Typically, these clinical signs all occur on the same side as the lesion with the exception of the fast phase of the nystagmus which occurs away from the lesion. However, lesions of the vestibulocerebellum will cause vestibular symptoms on the opposite side of the lesion, hence the term paradoxical vestibular disease.

Figure 1. Common neurologic examination findings in dogs with vestibular disease. A) leaning to the left and head tilt to the left. B) head tilt to the left. C) positional ventral strabismus OS

There are many causes of acute onset vestibular signs in older dogs. The first step in determining probable differentials is to determine whether the neuroanatomic localization is central or peripheral vestibular disease. What aides us in determining a specific neurolocalization with vestibular disease is not necessarily the vestibular symptoms (which can all look very similar no matter the specific localization), but rather the additional (i.e. non-vestibular) neurologic signs that can be caused by lesions in a given area. For example, with a lesion in the brainstem, you can expect to see not only vestibular signs, but also ipsilateral paresis, ipsilateral proprioceptive or postural reaction deficits, mentation change, and/or other ipsilateral cranial nerve deficits.  With a lesion in the vestibulocerebellum, one might expect to see other cerebellar symptoms such as proprioceptive or postural reaction deficits, wide based stance, truncal sway, hypermetria, dysmetria, or an intention tremor. Lastly, with a peripheral lesion, the only additional signs that may be seen are ipsilateral Horner’s syndrome and/or ipsilateral facial nerve paralysis. Correctly localizing a vestibular lesion to the central or peripheral vestibular system is critical in establishing appropriate differential diagnoses and thus an appropriate course of action.

Common causes of acute onset vestibular signs in old dogs include idiopathic vestibular disease, otitis media/interna, ischemic stroke, and neoplasia. Other important but less common causes may include hypothyroidism, toxins/drug (e.g. metronidazole), or meningoencephalitis. Important factors to consider when developing a differential list include:  the signalment of the dog; the rapidity of onset of clinical signs; whether the dog is exhibiting central or peripheral vestibular signs; whether the clinical signs have improved, remained static or gotten worse over time; and if the signs have improved, how rapidly have they improved (see Table 1).

Disease Central vs. Peripheral Change over Time
Idiopathic Vestibular Disease Peripheral Improvement starts after 2-3 days and continues over 1-2+ weeks
Otitis Media/Interna Peripheral Static or progressive
Ischemic Stroke Central Improvement at a variable rate from regression to normalcy within a few hours to improvement over several days or weeks
Neoplasia Central Static or progressive

Table 1: Summary of the common causes of acute onset vestibular disease in geriatric dogs, expected neuroanatomic localization, and expected development of clinical signs

In particular, it can be challenging to distinguish between idiopathic vestibular disease and ischemic stroke which both occur in geriatric dogs, have a per-acute onset, and get better over time without targeted therapy. Doing a thorough neurologic examination is critical in determining a specific neuroanatomic localization (i.e. central versus peripheral vestibular) which is the major factor in clinically distinguishing these two entities. Another factor to consider is recurrence of clinical signs. While idiopathic vestibular disease can recur in dogs after initial improvement, it is less common than with strokes and the interval between episodes is typically longer with idiopathic vestibular disease (months or more) versus strokes (days to weeks or more).

Some might ask, if dogs get better after a stroke without treatment (just like they do with idiopathic vestibular disease), why is there a need to distinguish between these two diseases? About 50% of dogs that suffer from strokes have an identifiable underlying cause that predisposes them to having continued strokes, and thus, puts them at risk for continued morbidity or even mortality. Possible underlying causes of strokes in dogs include:

  • Hypertension
  • Chronic kidney disease
  • Cushing’s disease
  • Hypothyroidism
  • Protein losing disease (enteropathy, nephropathy)
  • Hypercoagulability
  • Hyperviscosity (e.g. hyperglobulinemia secondary to multiple myeloma, polycythemia vera)
  • Tumor emboli

If a dog suffers a stroke, it is important to identify and treat any underlying cause(s) to help reduce the risk of further strokes and other morbidity. Diagnostic evaluation of a possible or confirmed stroke case should include:

  • Fundic exam
  • CBC
  • Chemistry panel
  • Urinalysis
  • Urine protein : creatinine ratio
  • Blood pressure
  • T4/TSH
  • +/- ACTH stimulation or low dose dexamethasone suppression test
  • +/- abdominal and thoracic imaging
  • +/- coagulation panel
  • +/- hypercoagulability assessment (i.e. TEG)

In summary, there are many causes of acute onset vestibular disease in geriatric dogs, some of which can be relatively easily managed if correctly identified (e.g. otitis media/interna, idiopathic vestibular disease). However, it can be very easy to make an incorrect presumptive diagnosis due to similarities in clinical presentation thus putting the patient at risk for further morbidity or even mortality. History or examination findings that warrant consideration of referral to a specialist for imaging (typically MRI) include progression of clinical signs over time, neurologic examination findings suggestive of central vestibular disease, and/or recurring vestibular episodes.

 

References

Garosi LS. Cerebrovascular disease in dogs and cats. Vet Clin North Am Sm Anim Pract. (2010). 40(1):65-79.

Garosi LS, Lowrie ML, Swinbourne NF. Neurological manifestations of ear disease in dogs and cats. Vet Clin North Am Sm Anim Pract. (2012). 42:6. 1142-60.

Lowrie ML. Vestibular disease: anatomy, physiology, and clinical signs. Compend Contin Educ Vet. (2012). 34(7): E1

Lowrie ML. Vestibular disease: diseases causing vestibular signs. Compend Contin Educ Vet. (2012). 34(7): E2

Sanders, SG. “Disorders of Hearing and Balance: The Vestibulocochlear Nerve (CN VIII) and Associated Structures.” Dewey CW, Da Costa RC. A Practical Guide to Canine and Feline Neurology. Ames, IA: Wiley Blackwell, 2016. 277 – 297.

Sanders, SG. “Cerebellar Diseases and Tremor Syndromes.” Dewey CW, Da Costa RC. A Practical Guide to Canine and Feline Neurology. Ames, IA: Wiley Blackwell, 2016. 299-307.

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