With the advent of many improved medical treatments every day, Angell Animal Medical Center is constantly striving to find new ways to care for and treat companion animals. New treatment options and improved technology allow Angell to consistently remain one of the leaders in veterinary care. One particular specialty service offered on site is the I‑131 therapy program directed by Dr. Jean Duddy. I‑131 is a radioactive iodine treatment for felines battling hyperthyroidism, a disease which causes increased thyroid levels in the blood.
What is Feline Hyperthyroidism?
Feline hyperthyroidism is caused by thyroid masses, most of which are benign (called adenoma), and a few of which are malignant (called carcinoma). Fortunately, both conditions can be treated by radioiodine (I‑131). For the adenoma (benign form), a small dose of I -131 is given. The goal is to kill the tumor cells and attain normal thyroid hormone levels so the body can return to a normal, healthy weight. The overall success rate of this treatment is approximately 98%. In the rare cases of adenocarcinoma (the malignant form) the goal is kill off all the thyroid tissue. These kitties require a much higher dose and are in the hospital a longer period of time. They also will require a thyroid supplement for life after the treatment. This would all be discussed before the treatment.
What are some symptoms of Feline Hyperthyroidism?
How Does I‑131 Work?
The only gland in the body to store iodine in the cells is the thyroid gland. The iodine we give is tagged with radiation so it is picked up by the blood stream, brought to the thyroid gland, and while it is in the gland waiting to be made into thyroid hormone, the radioactive iodine kills the tumor cells. After the thyroid tumor cells are killed, the thyroid level falls and the normal thyroid tissue that is left starts to produce thyroid hormone again.
Will the Radiation Hurt the Normal Thyroid Tissue?
The normal tissue is relatively “protected” from the radiation because thyroid tumor cells continuously over-produce thyroid hormone. During this time, the normal thyroid tissue turns off. This automatic decrease of thyroid production (in normal thyroid tissue) due to high thyroid hormone levels in the blood is called “negative feedback”. Tumor cells do not have this normal negative feedback mechanism. They continue to produce thyroid hormone no matter how high the thyroid level in the blood is at anytime. The tumor cells pick up the iodine tagged with radiation while the normal cells are not making thyroid hormone so they don’t pick up the radioactive iodine.
How Long Will the Treatment and Recovery Take?
Cats are admitted on Monday for any testing that needs to be done prior to the treatment. The thyroid scan and treatment (a single injection of I‑131) are done on Wednesday. The patients must remain hospitalized for 3 days post treatment so many owner’s pick up on Saturday following the treatment. There are litter and contact restrictions due to radiation safety concerns for 17 days post treatment. For owners who do not have the space or ability to deal with following these restrictions, these cats may remain at Angell for the entire restriction period. The thyroid level starts to fall in about 8-10 days so it can be a few weeks before cats stop losing weight and start to put weight back on. This is one of the reasons we recommend rechecking blood tests and weight 1 and 3 months post treatment.
What Makes Angell’s I‑131 Program Unique?
Whether your cat or your patient needs a thyroid scan for diagnosis, surgical evaluation, or pre-radioactive iodine treatment, we look forward to partnering with you to provide this service. If you have any questions regarding Angell’s I‑131 program, please email Dr. Duddy at firstname.lastname@example.org.
To schedule an appointment, or for further information please call the communication center at 617-522-7282.
Pricing, Safety, Requirements before Treatment, and Discharge Instructions.
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