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Animal Research Alternatives

S.584/H. 966: An Act concerning the use of animals in product testing

MSPCA Position: Support
Sponsors: Senator Mark Montigny and Representative Jack Patrick Lewis
Status: Referred to the Joint Committee on Environment, Natural Resources and Agriculture

Every year, tens of thousands of animals suffer and die in product testing in the U.S. In common toxicity testing, harsh chemicals are applied to an animal’s skin, forced down their throat or into their lungs, and dripped into their eyes—and pain relief is frequently withheld. These bills would require manufacturers and their contract testing facilities to use test methods that replace animal testing for products and ingredients when they are available and provide information of equivalent or better scientific quality and relevance for the intended purpose. The legislation applies to products such as cosmetics, household cleaners, and industrial chemicals, like those in paint; it does not apply to testing done for medical research, including testing of drugs or medical devices.

21st century science is rapidly moving away from outdated animal tests as many faster, less expensive, and more human-relevant alternative methods have become available, including artificial human tissue, organs-on-chips, and sophisticated computer programs. This shift toward non-animal methods builds on recommendations of the U.S. National Research Council’s 2007 report, Toxicity Testing in the 21st Century, which lays the groundwork for a “paradigm shift” in safety testing. It also conforms to the bipartisan-supported 2016 Frank R. Lautenberg Chemical Safety of the 21st Century Act, which requires the EPA to minimize animal testing. Additionally, EPA committed in 2019 to reduce reliance on mammalian animal testing by 30% by 2025 and to end it entirely by 2035.

Non-animal test methods save time and money. Non-animal alternatives provide more efficient as well as more effective chemical safety assessment. Human cell-based tests and advanced computer models, for example, deliver human-relevant results in hours or days, unlike some animal tests that can take months or years.

Animal tests do not ensure human safety. No longer considered the gold standard of product testing, animal models carry serious scientific limitations. Different species can respond differently when exposed to the same chemicals, and even different sexes or sub-species can react inconsistently. Consequently, results from animal tests may not be relevant to humans, under- or over-estimating health hazards. Alternative methods, based on human biology, are much more likely to provide results predictive of human responses.

Animals suffer in product tests. Every year, tens of thousands of animals suffer and die in product testing in the U.S. Thousands may be used for a single test, and they often suffer for months or years before being euthanized. The situation is all the more urgent given that mice, rats, and birds who have been purpose-bred for research make up roughly 95% of animals used in research and testing, and yet they are excluded from  the protection of the Animal Welfare Act.

Massachusetts is a scientific and technological leader in non-animal alternatives. Massachusetts consistently ranks as a top research dollars recipient of the National Institutes of Health (NIH), which, in its 2016-2020 strategic plan, stresses the importance of replacing animal testing models with scientifically superior alternative methods. As a top grant recipient, the Commonwealth has a vested interest in aligning its scientific goals and practices with those of the NIH. California, Maryland, New Jersey, New York, and Virginia, other top NIH research grant recipients, have already passed laws similar to this legislation. Last session, this legislation was released favorably from the Joint Committee on Environment, Natural Resources and Agriculture. It is time for Massachusetts to pass this legislation and join in leading the adoption of 21st century approaches to product safety testing.

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Co-Sponsors

Updated: 4/13/2021

State Senators:

Name District/Address
Mark C. Montigny Second Bristol and Plymouth
James B. Eldridge Middlesex and Worcester
Brendan P. Crighton Third Essex
Sal N. DiDomenico Middlesex and Suffolk

State Representatives:

Name District/Address
Jack Patrick Lewis 7th Middlesex
Steven G. Xiarhos 5th Barnstable
Lindsay N. Sabadosa 1st Hampshire
Natalie M. Higgins 4th Worcester
Tami L. Gouveia 14th Middlesex
Kay Khan 11th Middlesex
Brian W. Murray 10th Worcester
Lori A. Ehrlich 8th Essex
Adam J. Scanlon 14th Bristol
William C. Galvin 6th Norfolk
Kevin G. Honan 17th Suffolk
Tommy Vitolo 15th Norfolk
David Henry Argosky LeBoeuf 17th Worcester
Kate Lipper-Garabedian 32nd Middlesex
Brian M. Ashe 2nd Hampden
James K. Hawkins 2nd Bristol
Peter Capano 11th Essex
Michelle L. Ciccolo 15th Middlesex
Tram T. Nguyen 18th Essex
Danillo A. Sena 37th Middlesex
Daniel J. Ryan 2nd Suffolk
James Arciero 2nd Middlesex
Kip A. Diggs 2nd Barnstable

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